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严若峰

2014-10-8 19:55:52   来源:南京农业大学动物医学院   浏览:10

姓名

严若峰

性 别
出生日期

1976年8月

籍 贯

安徽岳西

毕业院校

研究方向:

寄生虫分子与免疫

兽医公共卫生 








个人简历:

博士,教授,博士生导师。南京农业大学优秀骨干教师。1994年9月-2001年7月就读于安徽农业大学动物医学院,先后获学士、硕士学位。2004年7月毕业于南京农业大学预防兽医学专业,获博士学位。2009年9月-2010年9月以访问学者身份在加拿大McGill大学进行合作研究。2014年9月-2016年1月新疆农业大学动物医学院(援疆)副院长。主持国家自然科学基金、国家973项目子课题、江苏省自然科学基金、中央高校基本科研业务费重点创新项目,参加国家863、国家行业(农业)公益项目等项目。参加国家精品课程、国家精品资源共享课程《兽医寄生虫病学》的教学与建设。发表论文90多篇,参编、主编教材9部,获国家发明专利9项。



 

代表性论著:

(1) Fang Wang, Lixin Xu, Xiaokai Song, Xiangrui Li, Ruofeng Yan*. Identification of differentially expressed proteins between free-living and activated third-stage larvae of Haemonchus contortus. Veterinary parasitology, 2016, 215(1): 72-77
(2) Wang S, Hassan IA, Liu X, Xu L, Yan R, Song X, Li X. Immunological changes induced by Toxoplasma gondii Glutathione-S-Transferase (TgGST) delivered as a DNA vaccine. Res Vet Sci. 2015, 99:157-164
(3) Yuan C, Zhang H, Wang W, Li Y, Yan R, Xu L, Song X, Li X. Transmembrane protein 63A is a partner protein of Haemonchus contortus galectin in the regulation of goat peripheral blood mononuclear cells. Parasit Vectors. 2015, 8: 211
(4) Huang J, Zhang Z, Li M, Song X, Yan R, Xu L, Li X. Eimeria maxima microneme protein 2 delivered as DNA vaccine and recombinant protein induces immunity against experimental homogenous challenge. Parasitol Int. 2015, 64(5):408-416 Huang J, Zhang Z, Li M, Song X, Yan R, Xu L, Li X. Immune protection of Microneme 7 (EmMIC7) against Eimeria maxima challenge in chickens. Avian Pathol. 2015, 16:1-35
(5) Song X, Zhang R, Xu L, Yan R, Li X. Chimeric DNA vaccines encoding Eimeria acervulina macrophage migration inhibitory factor (E.MIF) induce partial protection against experimental Eimeria infection. Acta Parasitol. 2015, 60(3): 500-508
(6) Song X, Ren Z, Yan R, Xu L, Li X. Induction of protective immunity against Eimeria tenella, Eimeria necatrix, Eimeria maxima and Eimeria acervulina infections using multivalent epitope DNA vaccines. Vaccine. 2015, 33(24): 2764-2770
(7) Song X, Huang X, Yan R, Xu L, Li X. Efficacy of chimeric DNA vaccines encoding Eimeria tenella 5401 and chicken IFN-γ or IL-2 against coccidiosis in chickens. Exp Parasitol. 2015, 156:19-25
(8) Song X, Xu L, Yan R, Huang X, Li X. Construction of Eimeria tenella multi-epitope DNA vaccines and their protective efficacies against experimental infection. Vet Immunol Immunopathol. 2015, 166(3-4):79-87
(9) Ibrahim A. HASSAN, S. WANG, L. XU, R. YAN, X. SONG & L. XIANGRUI. Immunological response and protection of mice immunized with plasmid encoding Toxoplasma gondii glycolytic enzyme malate dehydrogenase. Parasite Immunology, 2014, 36, 674–683
(10) Ibrahim A Hassan, Shuai Wang, LiXin Xu, RuoFeng Yan, XiaoKai Song and Xiangrui Li. DNA vaccination with a gene encoding Toxoplasma gondii Deoxyribose Phosphate Aldolase (TgDPA) induces partial protective immunity against lethal challenge in mice. Parasites & Vectors 2014, 7:431
(11) Ibrahim A. Hassan, Shuai Wang, LiXin Xu, RuoFeng Yan, XiaoKai Song, XiangRui Li. Immunoglobulin and cytokine changes induced following immunization with a DNA vaccine encoding Toxoplasma gondii selenium-dependent glutathione reductase protein. Experimental Parasitology, 2014, 146: 1–10
(12) Shuai Wang, GuangWei Zhao, Wang Wang, Qing Xie, Meng Zhang, Cheng Yuan, I. A. Hassan, XinChao Liu, LiXin Xu, RuoFeng Yan, XiaoKai Song, XiangRui Li*. Pathogenicity of two Toxoplasma gondii strains to chickens of different ages infected via intraperitoneal injection. Avian Pathology, 2014, 43(1): 1-5
(13) Wang W, Yuan C, Wang S, Song X, Xu L, Yan R, Hasson IA, Li X. Transcriptional and proteomic analysis reveal recombinant galectins of Haemonchus contortus down-regulated functions of goat PBMC and modulation of several signaling cascades in vitro. J Proteomics, 2014, 98:123-37
(14) Zhang M, Yang Z, Wang S, Tao L, Xu L, Yan R, Song X, Li X. Detection of Toxoplasma gondii in shellfish and fish in parts of China. Vet Parasitol, 2014, 200(1-2):85-89
(15) Yan ruofeng, Song xiaokai, Xu lixin, Li xiangrui. Phylogenetic analysis of Haemonchus contoutus based on the ITS gene. Chinese Journal of animal and veterinary sciences, 2014,45(S):66-70
(16) Ruofeng Yan, Jingjing Wang, Lixin Xu, Xiaokai Song and Xiangrui Li. DNA vaccine encoding Haemonchus contortus. Actin induces partial protection in Goats. Acta Parasitologica, 2014, 59(4), 698-709
(17) Wang W, Wang S, Zhang H, Yuan C, Yan R, Song X, Xu L, Li X. Galectin Hco-gal-m from aemonchus contortus modulates goat monocytes and T cell function in different patterns. Parasites & Vectors, 2014, 7: 342
(18) Tran Duc Hoan, Doan Thi Thao, Javaid Ali Gadahi, Xiaokai Song, Lixin Xu, Ruofeng Yan, Xiangrui Li. Analysis of humoral immune response and cytokines in chickens vaccinated with Eimeria brunetti apical membrane antigen-1(EbAMA1) DNA vaccine. Experimental Parasitology 2014,144: 65–72
(19) Ruofeng Yan , Lixin Xu , Jingjing Wang , Xiaokai Song, Xiangrui Li. Cloning and Characterization of Aldolase from Parasitic Nematode Haemonchus contortus. Journal of Animal and Veterinary Advances, 2013, 12(4): 478-486
(20) Zhikai Zhang, Lixin Xu, Xiaokai Song, Xiangrui Li, Ruofeng Yan*. Characterization of HcMSP, a novel gender specific gene from parasitic nematode Haemonchus contortus. Journal of Animal and Veterinary Advances, 2013, 12(5): 593-599
(21) Ruofeng Yan, Wei Sun, Xiaokai Song, Lixin Xu, Xiangrui Li. Vaccination of goats with DNA vaccine encoding Dim-1 induced partial protection against Haemonchus contortus : A preliminary experimental study. Research in Veterinary Science, 2013, 95: 189-199
(22) Hongyan Song, Baofeng Qiu, Ruofeng Yan, Lixin Xu, Xiaokai Song, Xiangrui Li. The protective efficacy of chimeric SO7/IL-2 DNA vaccine against coccidiosis in chickens. Research in Veterinary Science, 2013, 94 (3): 562-567
(23) Kaikai Han, Lixin Xu, Ruofeng Yan, Xiaokai Song, Xiangrui Li. Molecular cloning, expression and characterization of enolase from adult Haemonchus contortus. Research in Veterinary Science, 2012, 92 (2): 259-265
(24) GuangWei Zhao, RuoFeng Yan, Charles I. Muleke, YanMing Sun, LiXin Xu, XiangRui Li. Vaccination of goats with DNA vaccines encoding H11 and IL-2 induces partial protection against Haemonchus contortus infection. The Veterinary Journal, 2012, 191: 94-100
(25) GuangWei Zhao, Bo Shen, Qing Xie, Li Xin Xu, Ruo Feng Yan, Xiao Kai Song, I.A. Hassan, Xiang Rui Li. Detection of Toxoplasma gondii in free-range chickens in China based on circulating antigens and antibodies. Veterinary Parasitology, 2012, 185(2-4):2-77
(26) Wei Sun, Xiaokai Song, Ruofeng Yan, Lixin Xu, Xiangrui Li. Cloning and characterization of a selenium-independent glutathione peroxidase (HC29) from adult Haemonchus contortus. J Vet Sci, 2012, 13(1), 49-58
(27) Kaikai Han, Lixin Xu, Ruofeng Yan, Xiaokai Song, Xiangrui Li. Vaccination of goats with glyceraldehyde-3-phosphate dehydrogenase DNA vaccine induced partial protection against Haemonchus contortus. Veterinary Immunology and Immunopathology, 2012, 149(3-4): 177-185
(28) Ruofeng Yan, Ludmel Urdaneta-Marquez, Kathy Keller, Catherine E James, Mary W Davey, Roger K Prichard. The role of several ABC transporter genes in ivermectin resistance in Caenorhabditis elegans. Veterinary Parasitology, 2012,190(3-4):519-529
(29) HUILI ZHU, LIXIN XU, RUOFENG YAN, XIAOKAI SONG, FANG TANG, SONG WANG and XIANGRUI LI. Identification and characterization of a cDNA clone-encoding antigen of Eimeria acervulina. Parasitology.2012, 139(13):1711-1719
(30) Huili Zhu, Ruofeng Yan, Song Wang, Xiaokai Song, Lixin Xu, Xiangrui Li. Identification and molecular characterization of a novel antigen of Eimeria acervulina. Molecular and Biochemical Parasitology, 2012,186(1): 21-28
(31) Guang-wei ZHAO, Bo SHEN, Qing XIE, Li-xin XU, Ruo-feng YAN, Xiao-kai SONG, Hassan Ibrahim Adam, Xiang-rui LI. Isolation and Molecular Characterization of Toxoplasma gondii from Chickens in China. Journal of Integrative Agriculture, 2012, 11(8): 1347-1353
(32) F. Tang, L. Xu, R. Yan, X. Song and X.Li. Evaluation of the immune response induced by DNA vaccines expressing MIF and MCD-1 genes of Trichinella spiralis in BALB/c mice. Journal of Helminthology, 2012, 86(4):430-439
(33) F. Tang, L. Xu, R. Yan, X. Song and X. Li. A DNA vaccine co-expressing Trichinella spiralis MIF and MCD-1 with murine ubiquitin induces partial protective immunity in mice. Journal of Helminthology, 2013, 87(1): 24–33
(34) Muhammad Ali A. Shah, Xiaokai Song, Lixin Xu, Ruofeng Yan, Xiangrui Li, Construction of DNA vaccines encoding Eimeria acervulina cSZ-2 with chicken IL-2 and IFN-c and their efficacy against poultry coccidiosis. Research in Veterinary Science, 2011, 90: 72–77
(35) Wei Sun, Xiaokai Song, Ruofeng Yan, Lixin Xu, Xiangrui Li. Vaccination of goats with a glutathione peroxidase DNA vaccine induced partial protection against Haemonchus contortus infection. Veterinary Parasitology, 2011, 182: 239–247
(36) Han Kai kai, Xu Lixin, Yan Ruofeng, Song Xiaokai, Li Xiangrui. Cloning, expression and characterization of NAD(+)-dependent glyceraldehyde-3-phosphate dehydrogenase of adult Haemonchus contortus. Journal of Helminthology,2011,85(4):421-429
(37) Liheng Liu, Lixin Xu, Fengbin Yan, Ruofeng Yan, Xiaokai Song, Xiangrui Li. Immunoproteomic analysis of the second-generation merozoite proteins of Eimeria tenella. Veterinary Parasitology, 2009, 164(2-4): 173-182
(38) Mohammed Ali A. Shah, Lixin Xu, Ruofeng Yan, Xiaokai Song, Xiangrui Li. Cross immunity of DNA vaccine pVAX1-cSZ2-IL-2 to Eimeria tenella, E. necatrix and E. maxima. Experimental Parasitology, 2010, 124: 330–333
(39) Mohammad Ali A. Shah, Roufeng Yan, Lixin Xu, Xiaokai Song, Xiangrui Li. A recombinant DNA vaccine encoding Eimeria acervulina cSZ-2 induces immunity against experimental E. tenella infection. Veterinary Parasitology, 2010, 169(1-2):185-189
(40) Hongyan Song, Ruofeng Yan, Lixin Xu, Xiaokai Song, Muhammad Ali A Shah, Huili Zhu, Xiangrui Li. Efficacy of DNA vaccines carrying Eimeria acervulina lactate dehydrogenase antigen gene against coccidiosis. Experimental Parasitology 2010, 126(2): 224–231
(41) Hongyan Song, Xiaokai Song, Lixin Xu, Ruofeng Yan, Muhammad Ali A. Shah, Xiangrui Li. Changes of cytokines and IgG antibody in chickens vaccinated with DNA vaccines encoding Eimeria acervulina lactate dehydrogenase. Veterinary Parasitology, 2010, 173(3-4): 219-227
(42) Shah MA, Song X, Xu L, Yan R, Song H, Ruirui Z, Chengyu L, Li X. The DNA-induced protective immunity with chicken interferon gamma against poultry coccidiosis Parasitology Research, 2010, 107(3):747–750
(43) Fengbin Yan, Lixin Xu, Liheng Liu, Ruofeng Yan, Xiaokai Song, Xiangrui Li . Immunoproteomic analysis of whole proteins from male and female adult Haemonchus contortus. The Veterinary Journal, 2010, 185(2): 174-179
(44) YI Daosheng, XU Lixin, YAN Ruofeng, LI Xiangrui. Haemonchus contortus: Cloning and characterization of serpin. Experimental Parasitology, 2010, 125(4):  363-370
(45) Xiaokai Song, Lixin Xu, Ruofeng Yan, Xinmei Huang, Mohammed Ali A. Shah, Xiangrui Li. The optimal immunization procedure of DNA vaccine pcDNA-TA4-IL-2 of Eimeria tenella, its cross immunity to Eimeria necatrix and Eimeria acervulina. Veterinary parasitology, 2009, 159(1): 30-36
(46) Liheng Liu, Lixin Xu, Fengbin Yan, Ruofeng Yan, Xiaokai Song, Xiangrui Li. Immunoproteomic analysis of the second-generation merozoite proteins of Eimeria tenella. Veterinary Parasitology, 2009, 164(2-4): 173-182
(47) Qianming Xu, Xiaokai Song, Lixin Xu, Ruofeng Yan, Mohammed Ali A. Shah  Xiangrui Li.Vaccination of chickens with a chimeric DNA vaccine encoding Eimeria tenella TA4 and chicken IL-2 induces protective immunity against coccidiosis. Veterinary Parasitology,2008,156(3-4): 319-323
(48) Charles I. Muleke, Yan Ruofeng, Sun Yanming, Zhao Guangwei, Xu lixin, Li Xiangrui. Vaccination of goats against Haemonchus contortus with a recombinant cysteine Protease. Small Ruminant Research, 2007,73:95-102.
(49) Yanming Sun, Ruofeng Yan, Charles I. Muleke, Guangwei Zhao, Lixin Xu, Xiangrui Li. Recombinant galectins of Haemonchus contortus Parasite Induces Apoptosis in the Peripheral Blood Lymphocytes of Goat. International Journal of Peptide Research and Therapeutics. 2007,13(3):387-392
(50) Sun Yanming, Ruofeng Yan, Charles I. Mulek, Zhao Guangwei, Xu Lixin, Li Xiangrui. Vaccination of goats with recombinant galectin antigen induces partial protection against Haemonchus contortus infection. Parasite Immunology, 2007, 29:319-326
(51) Charles I. Muleke, Yan Ruofeng, Xu Lixin, Bo Xinwen, Li Xiangrui. Cloning and sequence analysis of Hemonchus Contortus HC58 cDNA. DNA Sequence, 2007, 18(3):176-183
(52) Jing Wang, Ruofeng Yan, Lixin Xu, Xiangrui Li. The second glutamic acid in the C-terminal CRD affects the carbohydrate-binding properties of recombinant galectins of Haemonchus contortus. Veterinary Parasitology, 2007, 148 (3-4): 247-255
(53) Charles I. Muleke, Yan Ruofeng, Xu Lixin, Sun Yanming, Li Xiangrui. Characterization of HC58cDNA, a putative cysteine protease from the parasite Haemonchus contortus (Erratum) J Vet Sci. 2006; 7(4):405

科研项目:
(1)主持江苏省自然科学基金(BK20141365):旋毛虫幼虫侵入宿主肌细胞的分子机制,2014年7月-2017年6月,10万。
(2)参加国家973基础研究计划(2015CB150300):牛羊重要寄生虫致病机制的分子基础(课题4),2015年1月-2019年8月。学术骨干,子课题负责人,126万。
(3)参加国家自然科学基金(31172308):捻转血矛线虫重组Galectin抑制山羊外周血淋巴细胞细胞因子转录的通路研究,2012年1月-2015年12月,62万。
(4)参加十二五农村领域国家科技计划(2011AA102A211-4):偶蹄动物用新型免疫佐剂的创制,2011年1月-2015年12月,17万。
(5)主持国家自然科学基金(31001059):捻转血矛线虫发育相关新基因Hcher-1功能研究,2011年1月-2013年12月,20万。
(6)主持中央高校基本科研业务费自主创新重点项目(KYZ201315):捻转血矛线虫入侵宿主的分子机制研究,2013年5月-2016年5月,40万。
(7)主持江苏省自然科学基金(BK2006145):山羊捻转血矛线虫免疫调节型DNA疫苗研究,2006年6月-2008年12月,7万。
(8)参加江苏省农业支撑计划(BE2009389):鸡球虫免疫调节型多价DNA疫苗的研制,2009年6月-2012年6月,30万。
(9)参加江苏省自然科学基金(BK2010145):毒害艾美耳球虫免疫蛋白组研究,2010年9月-2013年9月,9万。
(10)参加国家公益项目(200903036-04):日本血吸虫病、包虫病、弓形虫病和附红细胞体病等重要人畜共患寄生虫病的防控技术研究,2009年10月—2013年12月,174万。
(11)参加国家863(2006AA10A207):鸡球虫猪囊虫病基因工程疫苗研究创制,2006年12月-2010年10月,64万。
(12)参加国家863(2002aa241331):禽用抗球虫基因工程疫苗的研究,2002年1月-2005年12月,100万。
(13)参加国家自然科学基金(30571393):堆型艾美耳球虫免疫功基因组研究(30771617),2008年1月-2010年12月,30万。
(14)参加国家自然科学基金(30371078):捻转血矛线虫半乳糖凝集素在免疫合疾病发生中的作用及机理研究,2004年1月-2006年12月,19万。
(15)参加上海市科技兴农重点攻关项目(沪农科攻字2004第12-3号):上海奶牛主要原虫流行病调查和防治对策研究,2004年1月-2006年12月,4万。
荣誉及奖项:

(1)多媒体课件大赛优秀奖,教育部教育管理信息中心,2005

(2)希尔思奖教金,南京农业大学动物医学院,2005
(3)青年教师授课大赛优秀奖,南京农业大学动物医学院,2006
(4)2007年度考核优秀,南京农业大学,2007
(5)2008年度考核优秀,南京农业大学,2008
(6)上海科技成果奖,上海市科技局,2008
(7)“133重点人才工程”优秀骨干教师,南京农业大学,2010

(8)生泰尔奖教金,南京农业大学动物医学院,2010
(9)2014年度考核优秀,南京农业大学,2014
(10)2015年度考核优秀,南京农业大学,2015
(11)“优秀科研管理院长”,新疆农业大学,2015




联系方式:
地址:南京市卫岗1号 210095
电话:025-84395904
传真:025-84399000
Email:yanruofeng@njau.edu.cn




 
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