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Yong Sam Jung

2016-6-1 9:22:34   来源:南京农业大学动物医学院   浏览:10
姓名

Yong Sam Jung

性 别
出生日期

籍 贯

韩国

毕业院校

韩国培材(PaiChai)大学

研究方向:
病原与宿主相互作用分子机制
泛素化修饰通路在病毒感染致病过程中的作用机理

个人简历:
Yong Sam Jung,教授,博士生导师,1991-2005年韩国PaiChai大学基因工程专业(1993-1995服兵役),1998年获学士学位,2001年获硕士学位,2005年获博士学位。2005-2007年,韩国忠南国立大学生物技术研究所助理研究员,期间获韩国博士后研究基金项目资助,是韩国政府支持的5项有关心卒中和脑卒中疾病研究项目的主要完成人,在J Biol Chem, FEBS Letters, and Biochem Biophys Res Commun等国际知名刊物发表研究论文8篇,其中第一作者论文5篇,并获得韩国、美国、加拿大、澳大利亚等国专利10项,其中第一完成人专利5项;另有申请国际专利7项,其中第一完成人专利4项。2007-2013年,在美国加州大学戴维斯分校兽医学院比较肿瘤学研究中心从事博士后研究,承担和参与了4项美国NIH基金项目研究;从基因转录、转录后翻译及蛋白修饰等层面研究基因功能,取得了多项创新成果,在J Investi Dermatol, Proc Natl Acad Sci USA, Mol Cell Biol, J Biol Chem等国际权威期刊发表论文18篇,其中第一作者论文8篇,SCI他引370余次;任J Biol Chem, Oncogene, J Cell Sci等期刊论文评审人。2013年6月到南京农业大学动物医学院预防兽医学系工作。主要研究基因转录、转录后翻译及蛋白修饰等在病毒感染致病过程中的作用机理;研究病原与宿主相互作用分子机制;发现新的诊断标志物和病毒关键致病基因。



代表性论著:
第一作者研究论文:
1.Jung YS, Qian Y, Yan W, and Chen X. Pirh2 E3 ubiquitin ligase modulates keratinocyte differentiation through p63. J Investi Dermatol 2013; 133, 1178-1187. (*Top 1 in the dermatology field).

2.Qian Y*, Jung YS*, and Chen X. DEC1 controls the response of p53-dependent cell survival versus cell death to a stress signal through macrophage inhibitory cytokine-1. Proc Natl Acad Sci USA 2012; 109, 11300-11305. (*These authors contributed equally to the work).

3.Jung YS, Qian Y, and Chen X. DNA polymerase eta is targeted by Mdm2 for polyubiquitination and proteasomal degradation in response to ultraviolet irradiation. DNA Repair (Amst) 2011; 11(2), 177-184.

4.Jung YS, Qian Y, and Chen X. The p73 tumor suppressor is targeted by Pirh2 RING finger E3 ubiquitin ligase for the proteasome-dependent degradation. J Biol Chem 2011; 286, 35388-35395.

5.Jung YS, Hakem A, Hakem R, and Chen X. Pirh2 E3 ubiquitin ligase monoubiquitinates DNA polymerase eta to suppress translesion DNA synthesis. Mol Cell Biol 2011; 31, 3997-4006.

6.Jung YS, Liu G, and Chen X. Pirh2 E3 ubiquitin ligase targets DNA polymerase eta for 20S proteasomal degradation. Mol Cell Biol 2010; 30, 1041-1048.

7.Jung YS, Kim HY, Lee MG, Pouyssegur J, and Kim E. Physical interaction and functional coupling between Daxx and sodium hydrogen exchanger isoform 1, an implication regarding Daxx role in ischemic stress-induced cell death. J Biol Chem 2008; 283, 1018-1025.

8.Jung YS, Kim HY, Lee YJ, and Kim E. Subcellular localization of Daxx determines its opposing functions in ischemic cell death. FEBS Lett 2007; 581, 843-852.

9.Jung YS, Lee DH, Lim H, Yi KY, Yoo SE, and Kim E. KR-31378 protects cardiac H9c2 cells from chemical hypoxia-induced cell death via inhibition of JNK/p38 MAPK activation. Jpn J physiol 2004; 54, 575-583.

10.Jung YS, Jung YS, Kim MY, and Kim E. Identification of caspase-independent PKCε-JNK/p38 MAPK signaling module in response to metabolic inhibition in H9c2 cells. Jpn J physiol 2004; 54, 23-29.

11.Jung YS, Kim, KS, Kim, KD, Lim, JS, Kim, JW, and Kim, E. Apoptosis-linked gene 2 binds to the death domain of Fas and dissociates from Fas during Fas-mediated apoptosis in Jurkat cells. Biochem Biophys Res Commun 2001; 288, 420-426.

其他研究论文:
1.Cho SJ, Jung YS, and Chen X. Poly (C)-Binding Protein 1 Regulates p63 Expression through mRNA Stability. PLoS One 2013; 8, e71724.

2.Zhang Y, Yan W, Jung YS, and Chen X. PUMA Cooperates with p21 to Regulate Mammary Epithelial Morphogenesis and Epithelial-To-Mesenchymal Transition. PLoS One 2013; 8, e66464.

3.Cho SJ, Rossi A, Jung YS, Yan W, Liu G, Zhang J, Zhang M, and Chen X. Ninjurin1, a target of p53, regulates p53 expression and p53-dependent cell survival, senescence, and radiation-induced mortality. Proc Natl Acad Sci USA 2013; 110, 9362-9367.

4.Yan W, Chen X, Zhang Y, Zhang J, Jung YS, and Chen X. Arsenic suppresses cell survival via Pirh2-mediated proteasomal degradation of ΔNp63 protein. J Biol Chem 2013; 288, 2907-2913.

5.Yan W, Zhang J, Zhang Y, Jung YS, and Chen X. P73 expression is regulated by RNPC1, a target of the p53 family, via mRNA stability. Mol Cell Biol. 2012; 32, 2336-2348.

6.Zhang Y, Yan W, Jung YS, and Chen X. Mammary epithelial cell polarity is differentially regulated by p73 isoforms via epithelial-to-mesenchymal transition. J Biol Chem 2012; 287(21), 17746-17753.

7.Cho SJ, Jung YS, Zhang J, and Chen X. The RNA-binding Protein RNPC1 Stabilizes the mRNA Encoding the RNA-binding Protein HuR and Cooperates with HuR to Suppress Cell Proliferation. J Biol Chem 2012; 287(18),14535-14544.

8.Hakem A, Bohgaki M, Lemmers B, Tai E, Salmena L, Matysiak-Zablocki E, Jung YS, Karaskova J, Kaustov L, Duan S, Madore J, Boutros P, Sheng Y, Chesi M, Bergsagel PL, Perez-Ordonez B, Mes-Masson AM, Penn L, Squire J, Chen X, Jurisica I, Arrowsmith C, Sanchez O, Benchimol S, and Hakem R. Role of Pirh2 in Mediating the Regulation of p53 and c-Myc. PLoS Genet 2011; 11, e1002360.

9.Qian Y, Jung YS, and Chen X. DeltaNp63, a target of DEC1 and histone deacetylase 2, modulates the efficacy of histone deacetylase inhibitors in growth suppression and keratinocyte differentiation. J Biol Chem 2011; 286, 12033-12041.

10.Hwang IS, Jung YS, and Kim E. Interaction of ALG-2 with ASK1 influences ASK1 localization and subsequent JNK activation. FEBS Lett 2002; 529, 183-187.

11.Kim ES, Yoo SE, Yi KY, Lee S, Noh JS, Jung YS, Kim E, and Jeong N. Design, Syntheses and Biological Evaluations of Nonpeptidic Caspase 3 Inhibitors. Bull Korean Chem Soc 2002; 23, 1003-1010.

12.Cho SJ, Lee NS, Jung YS, Lee H, Lee KJ, Kim E, and Chae SK. Identification of structural domains affecting transactivation potential of Nm23. Biochem Biophys Res Commun 2001; 289, 738-743.

应邀综述:
1.Qian Y, Jung YS, and Chen X. DEC1 and MIC-1: new players of p53-dependent cell fate decision. 2012 Cell cycle 2012; 11, 3525-3526.

2.Jung YS, Qian Y, and Chen X. Pirh2 RING-finger E3 ubiquitin ligase: its role in tumorigenesis and cancer therapy. FEBS Lett 2012; 586, 1397-1402.

3.Jung YS, Qian Y, and Chen X. Examination of the expanding pathways for the regulation of p21 expression and activity. Cell Signal 2010; 22, 1003-1012.

获得专利:
1.Jung YS, Kim E, Kim NJ, Lee YS, Suh JH, Suh Kim HY, Yi KY, and Yoo SE. Aminopyrazole derivatives, process for the preparation thereof, and composition for preventing or treating ischemic diseases containing the same. 2011, Canada, 266975.

2.Jung YS, Kim E, Kim NJ, Lee YS, Suh JH, Suh Kim HY, Yi KY, and Yoo SE. Aminopyrazole derivatives, process for the preparation thereof, and composition for preventing or treating ischemic diseases containing the same. 2011, USA, 7939550.

3.Jung YS, Kim E, Kim NJ, Lee YS, Suh JH, Suh Kim HY, Yi KY, and Yoo SE. Aminopyrazole derivatives, process for the preparation thereof, and composition for preventing or treating ischemic diseases containing the same. 2011, Australia, 2007309854.

4.Seo JH, Yoo SE, Yi KY, Kim N, Kim E, Jung YS, Lee YS, Suh Kim HY. Benzofuran and Benzothiophene derivatives substituted by amide, process for the preparation thereof, and pharmaceutical compositions containing the same. 2010, Korea patent no. 10-2007-0103244.

5.Seo JH, Yoo SE, Yi KY, Kim N, Kim E, Jung YS, Lee YS, Suh Kim HY. Composition for preventing or treating an ischemic disease containing aminothiophene derivatives. 2008, Korea patent no. 10-0860539.

6.Seo JH, Yoo SE, Yi KY, Kim N, Kim E, Jung YS, Lee, YS, Suh Kim HY. N-phenylamide derivatives and preparation method thereof. 2008, Korea patent no. 10-0832751.

7.Seo JH, Yoo SE, Kim N, Kim E, Jung YS, Lee YS, Suh Kim HY. Composition for preventing or treating an ischemic disease containing N-phenylamide derivatives. 2008, Korea patent no. 10-0832750.

8.Jung YS, Kim E, Kim N, Lee YS, Seo JH, Suh Kim HY, Yi KY and Yoo SE. Aminopyrazole derivatives, process for the preparation thereof, and composition for preventing or treating ischemic diseases containing the same. 2008, Korea patent no 10-0832747.

9.Kim E, Lee YS, Jung YS, Yoo SE, Seo JH, Chae SK, and Lee KJ. Composition for treating an ischemic disease comprising a human FAF1 protein inhibitor as an active ingredient. 2008, Korea patent no. 10-0818752.

10.Jung YS, Lee DH, Kim E, and Lim H. Human Daxx protein and a fragment thereof as binding agents of human NHE1 ion channel protein. 2006, Korea patent no. 10-0597615-0000.





科研项目:
荣誉及奖项:
1.Korea Research Foundation Postdoctoral Fellowship, 2005-2006.

2.Best Poster Award, 2006 KSBMB (Korea Society for Biochemistry and Molecular Biology) Conference, Seoul, Korea.





联系方式:
地址:南京卫岗1号
邮编: 210095
办公电话: 02584399102
Email: yongsjung@gmail.com




 
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